反应详情

A solution of 2,5-dimethylpyrrolidine (0.334 mL, 2.73 mmol) and 4-[5-(chloromethyl)-1H-tetrazol-1-yl]benzonitrile (200 mg, 0.911 mmol, Intermediate 10) in acetonitrile (1.5 mL) was heated to 150° C. for 45 minutes in a microwave reactor. The reaction mixture was purified by high PH MDAP (2 injections). Relevant fractions were combined and the solvent removed. The resulting solid was partitioned between DCM (10 mL) and water (5 mL). The organic layer was collected via a hydrophobic frit and the solvent removed under vacuum to yield the title compound as a white solid (125 mg).

1. customThe reaction mixture was purified by high PH MDAP (2 injections)
2. customthe solvent removed
3. customThe resulting solid was partitioned between DCM (10 mL) and water (5 mL)
4. customThe organic layer was collected via a hydrophobic frit
5. customthe solvent removed under vacuum