HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 517787Generated: October 29, 2026
Hydrochloric Acid → 4-[5-(2,8-diazaspiro[4.5]dec-8-ylmethyl)-1H-tetrazol-1-yl]-2-(trifluoromethyl)benzonitrile
https://huagongshe.com/reaction/517787
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | HCID 86691872 | HCID 86691872 | — |
| Reactant | {1-[(4-cyano-3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2,8-diazaspiro[4.5]decane-2-carboxylate | HCID 86691901 | — |
| Product | 4-[5-(2,8-diazaspiro[4.5]dec-8-ylmethyl)-1H-tetrazol-1-yl]-2-(trifluoromethyl)benzonitrile | HCID 66654687 | — |
Reaction Steps
1,1-dimethylethyl 8-({1-[(4-cyano-3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2,8-diazaspiro[4.5]decane-2-carboxylate (Intermediate 35, 680 mg, 1.38 mmol) was treated with 4M HCl in dioxane (8 mL, 1.38 mmol) and solution was stirred at 25° C. for 1 hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09115132B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-02d1589a098f4c999ef76bc2730f89eb |
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| Source note | uspto-grants-2015_08 |
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