Ammonia → HCID 67524192, compound

HRID 517805Notes

Reaction equation

HRID 517805 reaction equation
[Cl:1][C:2]1[N:6]2[N:7]=[C:8](Cl)[CH:9]=[CH:10][C:5]2=[N:4][N:3]=1.[NH3:12]>O1CCOCC1>[Cl:1][C:2]1[N:6]2[N:7]=[C:8]([NH2:12])[CH:9]=[CH:10][C:5]2=[N:4][N:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14823463,6-Dichloro[1,2,4]triazolo[4,3-b]pyridazine

Product 1

HCID 67524192HCID 67524192, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 190 mg of commercial 3,6-dichloro[1,2,4]triazolo[4,3-b]pyridazine and 1 cm3 of aqueous ammonia at 35% in 1 cm3 of dioxane, in a sealed tube, is heated at between 70° C. and 90° C. for 3 h. The precipitate formed is filtered off, to give 156.4 mg of 3-chloro[1,2,4]triazolo[4,3-b]pyridazin-6-amine in the form of a beige powder, the characteristics of which are as follows:

Workup

  1. temperaturein a sealed tube, is heated at between 70° C. and 90° C. for 3 h
  2. customThe precipitate formed
  3. filtrationis filtered off

Sources & evidence

ORD record
ord-2325d2a08e084c319e07cd1be4e60636
Source dataset
uspto-grants-2015_08
Patent number
US09115134B2

Reaction notes

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