Acetic Anhydride → HCID 86707014, compound

HRID 517817Notes

Reaction equation

HRID 517817 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11]3[N:12]([C:14]([S:17][C:18]4[CH:27]=[CH:26][C:21]5[N:22]=[C:23]([NH2:25])[S:24][C:20]=5[CH:19]=4)=[N:15][N:16]=3)[N:13]=2)[CH:5]=[CH:6][CH:7]=1.[C:28](OC(=O)C)(=[O:30])[CH3:29]>N1C=CC=CC=1>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11]3[N:12]([C:14]([S:17][C:18]4[CH:27]=[CH:26][C:21]5[N:22]=[C:23]([NH:25][C:28](=[O:30])[CH3:29])[S:24][C:20]=5[CH:19]=4)=[N:15][N:16]=3)[N:13]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 42598896HCID 42598896, compound

Product 1

HCID 86707014HCID 86707014, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The N-(6-{[6-(3-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulphanyl}-1, benzothiazol-2-yl)acetamide can be prepared according to the method described in Example 18b, but using 100 mg of 6-{[6-(3-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulphanyl}-1,3-benzothiazol-2-amine in 5 cm3 of pyridine and 0.318 cm3 of acetic anhydride at 50° C. for 4 h. 54 mg of N-(6-{[6-(3-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)acetamide are thus obtained in the form of a white powder, the characteristics of which are as follows:

Workup

  1. customat 50° C.
  2. customfor 4 h

Sources & evidence

ORD record
ord-10369222bc1c4ad9a0714a9b16886d3c
Source dataset
uspto-grants-2015_08
Patent number
US09115134B2

Reaction notes

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