Sodium Hydroxide → HCID 71657646, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl 7-(2,3-bis(6-methylpyridin-3-yl)-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate (step 1)(16 mg, 0.034 mmol) in MeOH (2 ml) was treated with sodium hydroxide 1M (0.101 ml, 0.101 mmol) and the resulting solution was stirred at 25° C. for 68 hours. The solution was concentrated under vacuum and the residue was diluted with water and washed with EtOAc (×2). The aqueous was acidified (pH ˜4 with 1N HCl) and extracted with DCM (×3). The extracts were dried (MgSO4) and evaporated under vacuum to afford the titled compound;

Provenance & Evidence