Hydrochloric Acid → HCID 71656242, compound

Participants

Reaction Steps

To a solution of the mixture of compounds from step 1 (120 mg) in Ethanol (5 ml) was added 2M NaOH (aq) (0.478 ml, 0.956 mmol) and the suspension was stirred under an atmosphere of nitrogen at room temperature overnight. The resulting suspension was treated ethyl acetate (20 ml) followed by 2M HCl (aq) (˜3 ml) until pH 5-6 was reached. The resulting mixture was washed with water (˜20 ml). The organic layer was separated and dried over MgSO4, filtered and concentrated under reduced pressure to give a yellow oil/solid. Purification of the solid by chromatography on silica eluting with EtOAc in iso-hexane afforded the titled compound;

Provenance & Evidence