反应详情

A mixture comprising 5-chloropyridine-2,3-diamine (1 g, 6.9 mmol) and 1,2-di-p-tolylethane-1,2-dione (1.6 g, 6.9 mmol) in EtOH (15 ml) under argon was stirred at 70° C. overnight. The mixture was heated for a further 8 hours and the solvent was removed under reduced pressure. The resulting crude material was purified by chromatography on silica eluting with 5% EtOAc in hexane to afford the titled compound;

1. temperatureThe mixture was heated for a further 8 hours
2. customthe solvent was removed under reduced pressure
3. customThe resulting crude material was purified by chromatography on silica eluting with 5% EtOAc in hexane