6-Chloropyridine-2,3-diamine → 6-Ethyl-2,3-di-p-tolyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazine

HRID 517928Notes

Reaction equation

HRID 517928 reaction equation
C([CH:3]1[CH2:26][NH:25][C:6]2=[N:7][C:8]([C:18]3[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=3)=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=3)[N:10]=[C:5]2[CH2:4]1)C.Cl[C:28]1N=C(N)C(N)=C[CH:29]=1>>[CH2:28]([CH:26]1[NH:25][C:6]2=[N:7][C:8]([C:18]3[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=3)=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=3)[N:10]=[C:5]2[CH2:4][CH2:3]1)[CH3:29]

Participants

3

Reactant 2

HCID 106306156-Chloropyridine-2,3-diamineHCID 896898537-Ethyl-2,3-di-p-tolyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazine

Product 1

HCID 896899436-Ethyl-2,3-di-p-tolyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazine

Procedure

The titled compound was prepared analogously to Intermediate D by replacing 5-chloropyridine-2,3-diamine with 6-chloropyridine-2,3-diamine;

Sources & evidence

ORD record
ord-e65986716b414d4c952a4178aef040fe
Source dataset
uspto-grants-2015_08
Patent number
US09115129B2

Reaction notes

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