1,4-Dioxane → HCID 89689897, compound

Participants

Reaction Steps

A solution of tert-butyl 8-hydroxy-8-methyl-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate (step 3) (310 mg, 0.696 mmol) in 4M HCl in dioxane (2 ml, 8.00 mmol) was stirred at room temperature for 30 mins. The reaction mixture was concentrated under reduced pressure and the residue partitioned between saturated aqueous sodium bicarbonate and DCM. The organic portion was separated and the aqueous portion extracted with DCM (30 ml). The combined organic layers concentrated under reduced pressure to afford the titled compound;

Provenance & Evidence