2-Fluoropyridine → HCID 53329699, compound

Participants

Reaction Conditions

Reaction Steps

To 1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile TFA salt (170 mg) in DMSO (2 ml) was added 2-fluoropyridine (121 mg) and TEA (0.22 ml). The mixture was heated at 200° C. for 40 minutes, then purified by basic HPLC to give 1-methyl-6-(4-(2-(1-(pyridin-2-yl)piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile which was then converted to HCl salt by lypholising with 1M hydrochloric acid (1 ml) (50 mg).

Provenance & Evidence