関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Fluoropyridine | HCID 9746 | — |
| 反応物 | (3S)-3-Pyrrolidinemethanol | HCID 7446911 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (S)-(1-(pyridin-2-yl)pyrrolidin-3-yl)methanol | HCID 67294196 | 58.4% |
反応手順
(S)-Pyrrolidin-3-ylmethanol (9.89 mmol, 1 g), 2-fluoropyridine (29.7 mmol, 2.88 g) and triethylamine (49.4 mmol, 6.89 ml, 5.00 g) were dissolved in MeOH (2.5 ml) and heated to 150° C. for 1 hour in the microwave. The resulting residue was purified by silica chromatography, eluting with DCM—5% MeOH/DCM to afford (S)-(1-(pyridin-2-yl)pyrrolidin-3-yl)methanol (1.03 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09115126B2 |
|---|
| 出典データセット | uspto-grants-2015_08 |
|---|
| ORD ID | ord-e80e2012ce1c4ce8aaec60440275cec8 |
|---|
| 出典メモ | uspto-grants-2015_08 |
|---|
