Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-(4-(4-cyano-1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-2-(trifluoromethyl)phenoxy)propyl methanesulfonate | HCID 86673353 | — |
| Product | US9115126, Example 35 | HCID 53330392 | — |
Reaction Steps
A mixture of 3-(4-(4-cyano-1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-2-(trifluoro-methyl)phenoxy)propyl methanesulfonate (20 mg), diisopropylethylamine (73 μl) and dimethylamine in THF (2M, 1 ml) was heated at 100° C. under microwave conditions for 20 minutes. The mixture was purified by HPLC to give the expected product (6.3 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09115126B2 |
|---|
| Source dataset | uspto-grants-2015_08 |
|---|
| ORD ID | ord-f496b8a22efa47968c2c9382b6029aa4 |
|---|
| Source note | uspto-grants-2015_08 |
|---|
