Hydrochloric Acid → HCID 69932007, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of tert-butyl 2-(5-amino-6-cyano-4-(methylamino)-5′-(trifluoromethyl)-2,3′-bipyridin-6′-yloxy)ethyl(methyl)carbamate (160 mg) in water (3 ml) and 1,4-dioxane (3 ml), 2N hydrochloric acid (192 mg) was added at 0° C. and sodium nitrite (34.2 mg) in water (1 ml) was added then stirred at 0° C. for 10 min then at 20° C. for 20 h. The reaction mixture was filtered, washed with water, dried in vacuum oven to give 140 mg light yellow solid as tert-butyl 2-(5-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-3-(trifluoromethyl)pyridin-2-yloxy)ethyl(methyl)-carbamate (85%).

Provenance & Evidence