Potassium Phosphate, Tribasic → HCID 67294345, compound

Participants

Reaction Steps

tert-Butyl methyl(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)phenoxy)ethyl)carbamate (22.46 mmol, 10 g), 3-amino-6-chloro-4-(methylamino)picolinonitrile (22.46 mmol, 4.10 g), potassium phosphate (67.4 mmol, 14.30 g), tricyclohexylphosphine (2.69 mmol, 0.756 g), and tris(dibenzylacetone)-dipalladium (0) (1.123 mmol, 1.028 g) were dissolved in Dioxane (20 ml) and Water (10.00 ml) and stirred under nitrogen at 100° C. for 2 hrs. The mixture was diluted with ethyl acetate and filtered through celite. Organic layer was washed with water and separated from the aqueous layer, the organic layer was concentrated in vacuo. This was purified by silica chromatography, eluting with heptane—50/50 heptane/EtOAc to afford tert-butyl 2-(4-(5-amino-6-cyano-4-(methylamino)pyridin-2-yl)-2-(trifluoro-methyl)phenoxy)ethyl(methyl)carbamate. (2.11 g)

Provenance & Evidence