Dichloromethane → HCID 86673358, compound

Participants

Reaction Steps

To 6-(4-(3-hydroxypropyl)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile (0.65 g) in DMSO (10 ml) was added the DCM solution of Dess-Martin (15%, w/w) (10 ml). The mixture was stirred at rt for 2 hours. After diluting with ethyl acetate (150 ml), the mixture was washed with water (20 ml×4), brine (20 ml), dried over sodium sulphate, solvent removed under reduced pressure. The residue was then dissolved in ethyl acetate (20 ml). After standing overnight, precipitate was then filtered off, filtrate concentrated to give methyl-6-(4-(3-oxopropyl)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile (620 mg). 1H NMR (CDCl3) δ: 9.88 (s, 1H), 8.36 (s, 1H), 8.26 (d, 1H), 8.05 (s, 1H), 7.55 (d, 1H), 4.46 (s, 3H), 3.22 (t, 2H), 2.86 (t, 2H). MS m/z 360 (M+H).

Provenance & Evidence