HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-2-nitro-N-methylaniline → 4-Fluoro-N1-methylbenzene-1,2-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-2-nitro-N-methylaniline | HCID 2774662 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Fluoro-N1-methylbenzene-1,2-diamine | HCID 19964813 | 76.4% |
Reaction Steps
6.2 g (4-fluoro-2-nitrophenyl)-methylamine are suspended in 200 ml of ethyl acetate and hydrogenated with 1 g Raney nickel at a pressure of 5 bar and ambient temperature. After 4.5 hours the catalyst is suction filtered and the filtrate is evaporated to dryness. 3.9 g product are obtained as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115142B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-de6e9466799e41f5b5bf8e1953b62612 |
| Source note | uspto-grants-2015_08 |