HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 518110Generated: October 31, 2026
8-Benzyl-6,7,8,9-tetrahydropyrazino[2,3-f][1,4]oxazepin-3-amine → 6,7,8,9-Tetrahydropyrazino[2,3-f][1,4]oxazepin-3-amine
https://huagongshe.com/reaction/518110
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 8-Benzyl-6,7,8,9-tetrahydropyrazino[2,3-f][1,4]oxazepin-3-amine | HCID 66993139 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6,7,8,9-Tetrahydropyrazino[2,3-f][1,4]oxazepin-3-amine | HCID 59619527 | 35% |
Reaction Steps
A mixture of 8-benzyl-6,7,8,9-tetrahydropyrazino[2,3-f][1,4]oxazepin-3-amine (87 mg), 20% Pd(OH)2/C (150 mg) and methanol (2 ml) was stirred under a hydrogen atmosphere at 50° C. for 1 hr. Insoluble material was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by recrystallization (ethanol-hexane) to give the title compound (19.7 mg, 35%) as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09115139B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-7818f9a4bd9e472b83691ead503744eb |
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| Source note | uspto-grants-2015_08 |
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