HRID518157

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1CCC2(CC1)Oc1ccc(Br)cc1C2=O

HCID11474505

未命名化合物

结构：COC(=O)/C=C/c1ccc2c(c1)C(=O)CC1(CCNCC1)O2

HCID52952093

未命名化合物

PRODUCTS

生成物

结构：COC(=O)/C=C/c1ccc2c(c1)C(=O)C1(CCN(C(=O)OC(C)(C)C)CC1)O2

HCID11406566

未命名化合物

结构：COC(=O)/C=C/c1ccc2c(c1)C(=O)C1(CCNCC1)O2

HCID52952195

未命名化合物

PROCEDURE

实验过程

(E)-3-{1′-Tert-butoxycarbonyl-3-oxo-spiro[benzofuran-2(3H), 4′-piperidin]-5-yl}-acrylic acid methyl ester was synthesized according to the procedure for preparation of Intermediate 1, Step B starting from 5-bromo-3-oxo-spiro[benzofuran-2(3H), 4′-piperidin]-1′-carboxylic acid tert-butyl ester. Purification by column chromatography (eluent hexane/AcOEt:80/20 to 70/30) furnished the desired compound (780 mg).

WORKUP

后处理

customPurification by column chromatography (eluent hexane/AcOEt:80/20 to 70/30)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bcd76ef309754d07aad3c4b336cbdbb5
来源数据集: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09115148B2
来源说明: uspto-grants-2015_08

反应 SMILES

[CH3:1][O:2][C:3](=[O:22])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[C:8]2[C:18](=[CH:19][CH:20]=1)[O:17][C:11]1([CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)C[C:9]2=[O:21].[C:23]([O:27][C:28]([N:30]1[CH2:35][CH2:34][C:33]2([C:39](=[O:40])[C:38]3[CH:41]=[C:42](Br)[CH:43]=[CH:44][C:37]=3[O:36]2)[CH2:32][CH2:31]1)=[O:29])([CH3:26])([CH3:25])[CH3:24]>>[CH3:1][O:2][C:3](=[O:22])/[CH:4]=[CH:5]/[C:42]1[CH:43]=[CH:44][C:37]2[O:36][C:33]3([CH2:34][CH2:35][N:30]([C:28]([O:27][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:29])[CH2:31][CH2:32]3)[C:39](=[O:40])[C:38]=2[CH:41]=1.[CH3:1][O:2][C:3](=[O:22])/[CH:4]=[CH:5]/[C:6]1[CH:20]=[CH:19][C:18]2[O:17][C:11]3([CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[C:9](=[O:21])[C:8]=2[CH:7]=1