HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-3-{1'-Tert-butoxycarbonyl-3-oxo-spiro[benzofuran-2(3H), 4'-piperidin]-5-yl}-acrylic acid methyl ester → (E)-3-{3-oxo-spiro[benzofuran-2(3H), 4'-piperidin]-5-yl}-acrylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-3-{1'-Tert-butoxycarbonyl-3-oxo-spiro[benzofuran-2(3H), 4'-piperidin]-5-yl}-acrylic acid methyl ester | HCID 11406566 | — |
| Reactant | (E)-3-{4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester | HCID 52952093 | — |
| Product | (E)-3-{3-oxo-spiro[benzofuran-2(3H), 4'-piperidin]-5-yl}-acrylic acid methyl ester | HCID 52952195 | — |
Reaction Steps
(E)-3-{3-Oxo-spiro[benzofuran-2(3H), 4′-piperidin]-5-yl}-acrylic acid methyl ester was synthesized according to the procedure for preparation of Intermediate 1, Step C, starting from (E)-3-{1′-tert-butoxycarbonyl-3-oxo-spiro[benzofuran-2(3H), 4′-piperidin]-5-yl}-acrylic acid methyl ester (750 mg, 1.93 mmol), giving its hydrochloride salt (380 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115148B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-40e3e63d7be24d528134de77ae4f91ba |
| Source note | uspto-grants-2015_08 |