HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-4-piperidone → 6-Bromo-1'-methylspiro[chroman-2,4'-piperidin]-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-4-piperidone | HCID 74049 | — |
| Reactant | 5'-Bromo-2'-hydroxyacetophenone | HCID 95991 | — |
| Reactant | (E)-3-{1'-tert-butoxycarbonyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester | HCID 52952087 | — |
| Product | 6-Bromo-1'-methylspiro[chroman-2,4'-piperidin]-4-one | HCID 57720805 | — |
Reaction Steps
1′-Methyl-6-bromo-spiro[chromane-2,4′-piperidine]-4-one was synthesized according to the procedure for the preparation of Intermediate 1, Step A, using N-methyl-4-piperidone (1.13 g, 10 mmol), and 2-hydroxy-5-bromoacetophenone to give an orange solid (2.29 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115148B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-651c21b9a62b426dbe31930845b97921 |
| Source note | uspto-grants-2015_08 |