HuagongsheHuagongshe Chemistry Print Report · For research reference only
5'-Bromo-2'-hydroxyacetophenone → 1'-Phenyl-6-bromo-spiro[chromane-2,4'-piperidine]-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5'-Bromo-2'-hydroxyacetophenone | HCID 95991 | — |
| Reactant | 1-Phenyl-4-piperidinone | HCID 413009 | — |
| Reactant | (E)-3-{1'-tert-butoxycarbonyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester | HCID 52952087 | — |
| Product | 1'-Phenyl-6-bromo-spiro[chromane-2,4'-piperidine]-4-one | HCID 66932220 | — |
Reaction Steps
1′-Phenyl-6-bromo-spiro[chromane-2,4′-piperidine]-4-one was synthesized according to the procedure for preparation of Intermediate 1, Step A, using 1-phenyl-piperidin-4-one (607 mg, 3.47 mmol) and 2-hydroxy-5-bromoacetophenone (746 mg, 3.47 mmol), giving 650 mg as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115148B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-c0950ea8371547d0926ea53da7c061be |
| Source note | uspto-grants-2015_08 |