HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl acrylate → (E)-3-{1-Benzyl-3',4'-dihydro-4'-oxo-spiro[piperidine-4,2'(1'H)-quinazoline]-6'-yl}-acrylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl acrylate | HCID 15458 | — |
| Reactant | 1-benzyl-6'-bromo-3',4'-dihydro-spiro[piperidine-4,2'(1H)-quinazoline]-4'-one | HCID 46077949 | — |
| Reactant | (E)-3-{1'-tert-butoxycarbonyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester | HCID 52952087 | — |
| Product | (E)-3-{1-Benzyl-3',4'-dihydro-4'-oxo-spiro[piperidine-4,2'(1'H)-quinazoline]-6'-yl}-acrylic acid tert-butyl ester | HCID 66932495 | — |
Reaction Steps
(E)-3-{1-Benzyl-3′,4′-dihydro-4′-oxo-spiro[piperidine-4,2′(1′H)-quinazoline]-6′-yl}-acrylic acid tert-butyl ester was synthesized starting from 1-benzyl-6′-bromo-3′,4′-dihydro-spiro[piperidine-4,2′(1′H)-quinazoline]-4′-one (600 mg, 1.55 mmol) and tert-butyl acrylate according to the procedure described for Intermediate 1, Step B, giving 486 mg of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115148B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-5683ea6afdaa4f3cae33f709d6e8add1 |
| Source note | uspto-grants-2015_08 |