HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-Chloro-6-methylbenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-Chloro-6-methylbenzoic acid | HCID 88870 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Chloro-6-methylbenzoyl chloride | HCID 22382040 | — |
Reaction Steps
To a solution of 2-chloro-6-methylbenzoicacid (339) (300 g, 1.76 mol, 1.0 eq) and DMF (0.5 mL) in DCM (500 mL) at RT, oxalyl chloride (249 g, 1.92 mol, 1.1 eq) was added slowly (over 5 min) The resulting mixture was stirred at RT for 2 h and then concentrated in vacuo to afford 2-chloro-6-methylbenzoyl chloride (340) which was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115141B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-3fd8d4169bd7452a8b36eee80bd7392e |
| Source note | uspto-grants-2015_08 |