Benzylamine → N-benzyl-5-bromo-2-methoxybenzamide

참여 물질

역할	이름	HCID	투입량
반응물	Benzylamine	HCID 7504	—
반응물	1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide	HCID 15908	—
반응물	1-Hydroxybenzotriazole	HCID 75771	—
반응물	Diisopropylethylamine	HCID 81531	—
반응물	5-Bromo-2-methoxybenzoic acid	HCID 881739	—
용매	Dimethylformamide	HCID 6228	—
용매	Dichloromethane	HCID 6344	—
생성물	N-benzyl-5-bromo-2-methoxybenzamide	HCID 1254086	90.4%

반응 단계

To an ice bath cooled mixture of 5-bromo-2-methoxybenzoic acid (439 mg, 1.9 mmol) in 1:1 CH2Cl2:DMF (4 mL) was added benzylamine (0.228 mL, 2.1 mmol), EDCI (438 mg, 2.3 mmol), HOBt (311 mg, 2.3 mmol) and NEtiPr2 (0.496 mL, 2.85 mmol). The mixture was then stirred at room temperature until the reaction was complete. Extractive work up with ethyl acetate, washing with saturated aqueous NaHCO3, H2O, saturated aqueous KHSO4 and brine, gave the title compound (550 mg) after isolation which was carried forward without purification. LCMS (M+H)+ 320, 322.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09115114B2
출처 데이터셋	uspto-grants-2015_08
ORD ID	ord-dd64335374804bb4a10dd1a978b38bf4
출처 메모	uspto-grants-2015_08