HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydropyridin-2-one → US10023592, Example 144
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydropyridin-2-one | HCID 71270309 | — |
| Reactant | 4-Chloro-5-(cyclopropylmethoxy)-2-(methylsulfonylmethyl)pyrimidine | HCID 118022136 | — |
| Product | US10023592, Example 144 | HCID 118021646 | — |
Reaction Steps
The title compound of Example 143, step 2 was reacted with 1,3-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-one in a manner similar to Example 143, step 3 to give the title compound. 1H NMR (CDCl3, 400 MHz) δ 8.49 (d, J=2.0 Hz, 1H), 8.18 (s, 1H), 7.60 (s, 1H), 3.86 (d, J=6.8 Hz, 2H), 3.67 (s, 3H), 3.11 (s, 3H), 2.24 (s, 3H), 1.29-1.27 (m, 1H), 0.72-0.67 (m, 2H), 0.39-0.35 (m, 2H). LCMS: 364.1 (M+1)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115114B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-6902869b2c154c2090346fc4fca24a46 |
| Source note | uspto-grants-2015_08 |