4-Chloro-5-(2,4-difluorophenoxy)-2-methylsulfonylpyrimidine → US10023592, Example 151

Participants

Role	Name	HCID	Charge
Reactant	4-Chloro-5-(2,4-difluorophenoxy)-2-methylsulfonylpyrimidine	HCID 118021544	—
Reactant	2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-1(2H)-one	HCID 123809499	—
Product	US10023592, Example 151	HCID 118021317	—

Reaction Steps

The title compound of Example 149, step 3 was reacted with the title compound of Example 89, step 1 in a manner similar to Example 149, step 4 to give the title compound. 1H NMR (CDCl3, 400 MHz) δ 8.52 (d, J=8.0 Hz, 1H), 8.32 (s, 1H), 7.68 (s, 3H), 7.59-7.56 (m, 1H), 7.14-7.08 (m, 1H), 7.05-7.00 (m, 1H), 6.96-6.92 (m, 1H), 3.72 (s, 3H), 3.39 (s, 3H). LCMS: 443.9 (M+1)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09115114B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-bcfe257ae3e048868199fbb6bf53ee86
Source note	uspto-grants-2015_08