8-Bromo-6-methylpyrido[4,3-d]pyrimidin-5(6H)-one → US10023592, Example 234

Participants

Role	Name	HCID	Charge
Reactant	8-Bromo-6-methylpyrido[4,3-d]pyrimidin-5(6H)-one	HCID 118021926	—
Reactant	8-Bromo-6-methyl-2-(1-methylpyrazol-4-yl)pyrido[4,3-d]pyrimidin-5-one	HCID 118022310	—
Reactant	2-(5-Ethylsulfonyl-2-propoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane	HCID 123570089	—
Reactant	2-[2-(2,4-Difluorophenoxy)-5-ethylsulfonylphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane	HCID 123959408	—
Product	US10023592, Example 234	HCID 118021443	—

Reaction Steps

The title compound of step 2 was substituted for the title compound of Example 225, step 2 and the title compound of Example 231, step 3 was substituted for the title compound of Example 224, step 4 and reacted in a similar manner as Example 225, step 3. 1H NMR (CDCl3, 400 MHz) δ 9.60 (s, 1H), 9.27 (s, 1H), 8.12 (s, 1H), 8.02 (d, J=2.0 Hz, 1H), 7.94 (dd, J1=8.8 Hz, J2=2.0 Hz, 1H), 7.32-7.25 (m, 1H), 7.15-7.09 (m, 1H), 7.03-6.97 (m, 2H), 3.70 (s, 3H), 3.27 (q, J=7.6 Hz, 2H), 1.30 (t, J=7.2 Hz, 3H). LCMS: 458.0 (M+H)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09115114B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-d96e50aa964e4a74ab2155d5175b774a
Source note	uspto-grants-2015_08