反应详情

温度

45 °C

Using a sealed tube, a solution of methyl 4-bromo-6-methyl-7-oxothieno[2,3-c]pyridine-2-carboxylate (250 mg, 65 mmol) in MeOH (6 mL) stirred at rt was treated with 2N NH3 in methanol (8 ml). The sealed tube was heated to 45° C. for 60 h. After cooling to 0° C., the resulting suspension was filtered; the filter cake was washed with cooled (0° C.) MeOH (3 mL) and isopropyl ether (3 mL) to afford the title compound (215 mg, 95%) as a white solid. LCMS (M+H)+=288.

1. temperatureAfter cooling to 0° C.
2. filtrationthe resulting suspension was filtered
3. washthe filter cake was washed
4. temperaturewith cooled (0° C.) MeOH (3 mL) and isopropyl ether (3 mL)