HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-2-iodo-4-(methylsulfonyl)benzene → 4-(2-Ethyl-5-methylsulfonylphenyl)-2-methylisoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-2-iodo-4-(methylsulfonyl)benzene | HCID 58521830 | — |
| Reactant | 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-1(2H)-one | HCID 123809499 | — |
| Product | 4-(2-Ethyl-5-methylsulfonylphenyl)-2-methylisoquinolin-1-one | HCID 118021991 | — |
Reaction Steps
The the title compound of Example 312, step 3 was reacted with the title compound of Example 89, step 1 in a manner similar to Example 312, step 4 to give the title compound. 1H NMR (400 MHz, CDCl3): δ 1.10 (3H, t, J=8.0 Hz), 2.51-2.56 (2H, m), 3.10 (3H, s), 3.67 (3H, s), 6.97-7.02 (2H, m), 7.52-7.59 (3H, m), 7.80 (1H, s), 7.97 (1H, d, J=8.0 Hz), 8.54 (1H, d, J=8.0 Hz). LCMS: 342 (M+1)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115114B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-6bf58cbfa9894ff18d3feb382a1ce4f7 |
| Source note | uspto-grants-2015_08 |