化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl valerate → US10023592, Example 350
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl valerate | HCID 10882 | — |
| 反応物 | Ethyl hexanoate | HCID 31265 | — |
| 反応物 | 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one | HCID 45480194 | — |
| 反応物 | HCID 72550334 | HCID 72550334 | — |
| 反応物 | US10023592, Example 146 | HCID 118021343 | — |
| 反応物 | 4-Chloro-2-methylsulfonyl-5-propylpyrimidine | HCID 118021558 | — |
| 反応物 | 5-Butyl-4-chloro-2-methylsulfonylpyrimidine | HCID 118021647 | — |
| 生成物 | US10023592, Example 350 | HCID 118021484 | — |
反応手順
Examples 351-356 in Table 19 were prepared in a similar multi-step manner as Example 300, step 1 wherein either ethyl pentanoate was converted to 4-chloro-2-methylsulfonyl-5-propylpyrimidine or ethyl hexanoate was converted to 5-butyl-4-chloro-2-methylsulfonylpyrimidine which were then each reacted with a) 3-methoxy-1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-one (described in Example 146, step 3), b) the title compound of Example 98, step 1, or c) 3-chloro-1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-one (described in Example 134) in a manner similar to Example 152, step 5 to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09115114B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-958129c3f413483bbff3763589223c5b |
| 出典メモ | uspto-grants-2015_08 |