(3-Fluoro-4-nitrobenzyloxy)triisopropylsilane → HCID 178501199, compound

HRID 518598Notes

Reaction equation

HRID 518598 reaction equation
F[C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[N+:20]([O-:22])=[O:21])[CH2:5][O:6][Si:7]([CH:14]([CH3:16])[CH3:15])([CH:11]([CH3:13])[CH3:12])[CH:8]([CH3:10])[CH3:9].[N+](C1C=NC=CC=1[NH:32][C@@H:33]1[CH2:38][CH2:37][C@H:36]([C:39]([O:41][CH3:42])=[O:40])[CH2:35][CH2:34]1)([O-])=O>>[N+:20]([C:19]1[CH:18]=[CH:17][C:4]([CH2:5][O:6][Si:7]([CH:14]([CH3:16])[CH3:15])([CH:11]([CH3:13])[CH3:12])[CH:8]([CH3:10])[CH3:9])=[CH:3][C:2]=1[NH:32][C@@H:33]1[CH2:34][CH2:35][C@H:36]([C:39]([O:41][CH3:42])=[O:40])[CH2:37][CH2:38]1)([O-:22])=[O:21]

Participants

3

Reactant 2

HCID 60195384(3-Fluoro-4-nitrobenzyloxy)triisopropylsilaneHCID 178501201HCID 178501201, compound

Product 1

HCID 178501199HCID 178501199, compoundYield 39.2%

Procedure

The title compound was prepared from (3-fluoro-4-nitrobenzyloxy)triisopropylsilane using the preparation for cis-methyl 4-(3-nitropyridin-4-ylamino)cyclohexanecarboxylate described above. The yield was 3.5 g (39.2% yield).

Sources & evidence

ORD record
ord-dd96d7d310564b31ad12553638f35cc5
Source dataset
uspto-grants-2015_08
Patent number
US09115127B2

Reaction notes

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