HCID 178472433, compound → HCID 178472393, compound

HRID 518604Notes

Reaction equation

HRID 518604 reaction equation
[NH2:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:4][CH2:3]1.[F:13][C:14]1[CH:43]=[CH:42][C:17]([C:18](/[N:20]=[C:21]2\NC3C=CC(CO)=CC=3[N:25]\2[C@@H:26]2[CH2:31][CH2:30][C@H:29]([C:32](OC)=[O:33])[CH2:28][CH2:27]2)=[O:19])=[CH:16][CH:15]=1>>[F:13][C:14]1[CH:43]=[CH:42][C:17]([C:18]([NH:20][C:21]2[N:1]([C@@H:2]3[CH2:3][CH2:4][C@H:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:6][CH2:7]3)[C:31]3[CH:30]=[C:29]([CH2:32][OH:33])[CH:28]=[CH:27][C:26]=3[N:25]=2)=[O:19])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 178472433HCID 178472433, compoundHCID 178501185HCID 178501185, compound

Product 1

HCID 178472393HCID 178472393, compound

Procedure

The title compound was prepared in 6 steps from cis-ethyl 4-aminocyclohexanecarboxylate using a method analogous to the preparation of cis-methyl 4-((E)-2-(4-fluorobenzoylimino)-6-(hydroxymethyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexanecarboxylate. MS m/z=440.2 [M+H]. Calc'd for C24H26FN3O4: 439.2.

Sources & evidence

ORD record
ord-1ff145ff82304f21b1c202d41a8e2cf9
Source dataset
uspto-grants-2015_08
Patent number
US09115127B2

Reaction notes

Loading…