HCID 178472433, compound → HCID 178472390, compound

HRID 518605Notes

Reaction equation

HRID 518605 reaction equation
[NH2:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:4][CH2:3]1.F[C:14]1[CH:43]=[CH:42][C:17]([C:18](/[N:20]=[C:21]2\[NH:22][C:23]3[CH:39]=[CH:38][C:37]([CH2:40][OH:41])=[CH:36][C:24]=3N\2[C@@H]2CC[C@H](C(OC)=O)CC2)=[O:19])=[CH:16][CH:15]=1>>[C:18](/[N:20]=[C:21]1\[NH:22][C:23]2[CH:24]=[CH:36][C:37]([CH2:40][OH:41])=[CH:38][C:39]=2[N:1]\1[C@@H:2]1[CH2:3][CH2:4][C@H:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:6][CH2:7]1)(=[O:19])[C:17]1[CH:42]=[CH:43][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 178472433HCID 178472433, compoundHCID 178501185HCID 178501185, compound

Product 1

HCID 178472390HCID 178472390, compound

Procedure

The title compound was prepared in 6 steps from cis-ethyl 4-aminocyclohexanecarboxylate using a method analogous to the preparation of cis-methyl 4-((E)-2-(4-fluorobenzoylimino)-6-(hydroxymethyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexanecarboxylate. MS m/z=422.2 [M+H]. Calc'd for C24H27N3O4: 421.2.

Sources & evidence

ORD record
ord-feda7443599a4fcda0c6b597b047c8fb
Source dataset
uspto-grants-2015_08
Patent number
US09115127B2

Reaction notes

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