N-1-adamantyl-6-((triisopropylsilyloxy)methyl)-1H-benzo[d]imidazol-2-amine → N-(1-Adamanty-6-(hydroxymethyl)-1H-benzo[d]imidazol-2-yl)benzamide

Participants

Reaction Steps

The title compound was prepared in 2 steps from N-1-adamantyl-6-((triisopropylsilyloxy)methyl)-1H-benzo[d]imidazol-2-amine using a method analogous to the preparation of cis-methyl 4-((E)-2-(4-fluorobenzoylimino)-6-(hydroxymethyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexanecarboxylate. The yield was 200 mg (37.7%, 2 steps). MS m/z=402.2 [M+H]. Calc'd for C25H27N3O2: 401.2.

Provenance & Evidence