HCID 178465147, compound → HCID 178513945, compound

Participants

Reaction Steps

The title compound was prepared in 5 steps from cis-methyl 4-(2-amino-6-((triisopropylsilyloxy)methyl)-1H-benzo[d]imidazol-1-yl)cyclohexanecarboxylate using a method analogous to the preparation of (E)-N-(1-(cis-4-(ethylcarbamoyl)cyclohexyl)-6-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-2(3H)-ylidene)-4-fluorobenzamide. MS m/z=460.2 [M+H]. Calc'd for C27H33N5O2: 459.3. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.28-1.45 (m, 2H) 1.46-1.58 (m, 4H) 1.60-1.82 (m, 4H) 2.08-2.25 (m, 2H) 2.29-2.45 (m, 4H) 2.54-2.61 (m, 1H) 2.61-2.87 (m, 2H) 3.40-3.56 (m, 2H) 4.56-5.01 (m, 1H) 6.87-6.94 (m, 1H) 7.12-7.22 (m, 1H) 7.31-7.41 (m, 1H) 7.43-7.53 (m, 4H) 7.54-7.63 (m, 1H) 7.96-8.52 (m, 2H) 12.76 (s, 1H).

Provenance & Evidence