HCID 178452063, compound → HCID 178522618, compound

Participants

Reaction Steps

The title compound was prepared from (E)-tert-butyl 4-(2-(benzoylimino)-6-(2-(piperidin-1-yl)ethoxy)-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)piperidine-1-carboxylate using a method analogous to the preparation of (E)-4-cyano-N-(1-(cis-4-((R)-2-methylpiperazine-1-carbonyl)cyclohexyl)-6-(2-(piperidin-1-yl)ethoxy)-1H-imidazo[4,5-c]pyridin-2(3H)-ylidene)benzamide (1.9 g, 97%). MS m/z=449.2 [M+H]. Calc'd for C25H32N6O2: 448.3. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.16-1.29 (m, 2H) 1.31-1.42 (m, 2H) 1.41-1.55 (m, 4H) 1.60-1.77 (m, 2H) 2.26-2.37 (m, 1H) 2.37-2.45 (m, 4H) 2.58-2.70 (m, 4H) 3.04-3.17 (m, 2H) 4.29-4.39 (m, 2H) 4.72-4.89 (m, 1H) 7.04-7.06 (m, 1H) 7.47-7.51 (m, 2H) 7.51-7.54 (m, 1H) 8.19-8.20 (m, 1H) 8.21-8.22 (m, 1H) 8.22-8.24 (m, 1H).

Provenance & Evidence