Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → HCID 178502730, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| 반응물 | HCID 178453971 | HCID 178453971 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 178502730 | HCID 178502730 | 93.5% |
반응 단계
To a suspension of cis-4-(tert-butoxycarbonylamino)cyclohexanecarboxylic acid (3 g, 12.33 mmol) in DCM (35 mL) was added CDI (4.00 g, 24.66 mmol) portion-wise. The resulting mixture was stirred for 1 hour, and then O,N-dimethylhydroxylamine hydrochloride (1.804 g, 18.50 mmol) was added, and the mixture was stirred at RT for 16 hours. Water (30 mL) was added, and the mixture was stirred for 1 hour and then extracted with DCM (50 mL). The organic layer was washed with brine (30 mL), dried over sodium sulfate and concentrated to afford tert-butyl cis-4-(methoxy(methyl)carbamoyl)cyclohexylcarbamate (3.3 g, 93% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09115127B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-f7e795a531604d6183e5be3f7720d572 |
| 출처 메모 | uspto-grants-2015_08 |