Hydrochloric Acid → HCID 178472391, compound

Participants

Reaction Steps

A round bottom flask under nitrogen was charged with cis-ethyl 4-((E)-6-(2-(benzyloxy)ethoxy)-2-(3-fluorobenzoylimino)-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclohexanecarboxylate (2.5 g, 4.46 mmol), 10% Pd/C (0.712 g, 0.669 mmol), EtOH (8.92 mL), and concentrated HCl (0.372 mL, 4.46 mmol). The reaction mixture was stirred under an atmosphere of hydrogen for 24 hours. The mixture was diluted with EtOH (50 mL) and filtered through Celite® brand filter aid. The cake was washed with DCM (50 mL), EtOH (50 mL), and MeOH (50 mL), and the filtrate was concentrated to dryness. The residue was dissolved in 2% MeOH/DCM (100 mL) and washed with aqueous NaHCO3 (50 mL). The organic layer was dried over sodium sulfate and concentrated under reduced pressure to afford cis-ethyl 4-((E)-2-(3-fluorobenzoylimino)-6-(2-hydroxyethoxy)-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclohexanecarboxylate as a tan solid (2.1 g, 100% yield). MS m/z=471.2 [M+H]. Calc'd for C24H27FN4O5: 470.2.

Provenance & Evidence