Hydrochloric Acid → HCID 178457826, compound

Participants

Reaction Conditions

Reaction Steps

cis-4-(2-Acetamido-6-(2-(piperidin-1-yl)ethoxy)-1H-imidazo[4,5-c]pyridin-1-yl)-N-isopropylcyclohexanecarboxamide (8.56 g, 18.19 mmol) was diluted with 2N HCl (aq) (91 mL, 182 mmol) and heated at 50° C. overnight. The reaction mixture was concentrated in vacuo, and purified via silica gel chromatography using 0-100% 90:10:1 DCM:MeOH:NH4OH in DCM to yield cis-4-(2-amino-6-(2-(piperidin-1-yl)ethoxy)-1H-imidazo[4,5-c]pyridin-1-yl)-N-isopropylcyclohexanecarboxamide (6.39 g, 82% yield). MS m/z=429.2 [M+H], calc 428.57 for C23H36N6O2.

Provenance & Evidence