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HRID518656

反应详情

EQUATION

反应方程式

HRID 518656 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)c1ccc(F)c(Cl)c1
HCID520989

3-Chloro-4-fluorobenzoic acid

C7H4ClFO2

结构：CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc4ccsc4c3)[nH]c3cnc(OCCN4CCCCC4)cc32)CC1
HCID178457785

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)c(Cl)c3)[nH]c3cnc(OCCN4CCCCC4)cc32)CC1
HCID178457818

未命名化合物

收率 45.4%

PROCEDURE

实验过程

The title compound was prepared using a method analogous to the preparation of (E)-N-(1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-6-(2-(piperidin-1-yl)ethoxy)-1H-imidazo[4,5-c]pyridin-2(3H)-ylidene)benzo[b]thiophene-6-carboxamide, using 3-chloro-4-fluorobenzoic acid. The material was purified via preparative HPLC (0.1% NH4OH in ACN/H2O) to provide (E)-3-chloro-4-fluoro-N-(1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-6-(2-(piperidin-1-yl)ethoxy)-1H-imidazo[4,5-c]pyridin-2(3H)-ylidene)benzamide (45.4% yield). MS m/z=585.4 [M+H], calc 585.12 for C30H38ClFN6O3.

WORKUP

后处理

  1. customThe title compound was prepared
  2. customThe material was purified via preparative HPLC (0.1% NH4OH in ACN/H2O)