反应详情

The title compound was prepared using a method analagous to the preparation of (E)-4-cyano-N-(1-(cis-4-(piperazine-1-carbonyl)cyclohexyl)-6-(2-(piperidin-1-yl)ethoxy)-1H-imidazo[4,5-c]pyridin-2(3H)-ylidene)benzamide, using 4-fluorobenzoyl isothiocyanate. MS m/z=578.2 [M+H], calc 577.69 for C31H40FN7O3. 1H NMR (CDCl3) δ ppm: 8.35 (dd, J=8.7, 5.7 Hz, 2H), 8.09 (s, 1H), 7.01-7.20 (m, 3H), 4.75-4.96 (m, 1H), 4.50 (t, J=1.0 Hz, 2H), 3.64-3.77 (m, 2H), 3.46-3.59 (m, 2H), 2.80-3.03 (m, 10H), 2.53-2.69 (m, 4H), 2.08-2.19 (m, 2H), 1.72-1.90 (m, 5H), 1.60-1.71 (m, 4H), 1.40-1.55 (m, 2H).