HCID 178457841, compound → HCID 178457840, compound

HRID 518666Notes

Reaction equation

HRID 518666 reaction equation
NC1C(N[C@@H]2CC[C@H](C(NC(C)C)=O)CC2)=CC(OCCN2CCCCC2)=NC=1.[OH:30][C:31]([CH:34]1[CH2:39][CH2:38][N:37]([C:40]2[CH:45]=[C:44]([NH:46][C@@H:47]3[CH2:52][CH2:51][C@H:50]([C:53]([NH:55][CH:56]([CH3:58])[CH3:57])=[O:54])[CH2:49][CH2:48]3)[C:43]([N+:59]([O-])=O)=[CH:42][N:41]=2)[CH2:36][CH2:35]1)([CH3:33])[CH3:32]>>[NH2:59][C:43]1[C:44]([NH:46][C@@H:47]2[CH2:52][CH2:51][C@H:50]([C:53]([NH:55][CH:56]([CH3:58])[CH3:57])=[O:54])[CH2:49][CH2:48]2)=[CH:45][C:40]([N:37]2[CH2:36][CH2:35][CH:34]([C:31]([OH:30])([CH3:33])[CH3:32])[CH2:39][CH2:38]2)=[N:41][CH:42]=1

Participants

3

Reactant 2

HCID 178457841HCID 178457841, compoundHCID 178457857HCID 178457857, compound

Product 1

HCID 178457840HCID 178457840, compound

Procedure

The title compound was synthesized using a method analogous to the preparation of cis-4-(5-amino-2-(2-(piperidin-1-yl)ethoxy)pyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide starting from cis-4-(2-(4-(2-hydroxypropan-2-yl)piperidin-1-yl)-5-nitropyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide (yellow solid). MS m/z=418.2 [M+H], calc 417.59 for C23H39N5O2.

Sources & evidence

ORD record
ord-b871a5e846f344ae8110aad4dc902bdd
Source dataset
uspto-grants-2015_08
Patent number
US09115127B2

Reaction notes

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