HCID 178457857, compound → HCID 178457865, compound

HRID 518667Notes

Reaction equation

HRID 518667 reaction equation
NC1C(N[C@@H]2CC[C@H](C(NC(C)C)=O)CC2)=CC(OCCN2CCCCC2)=NC=1.[CH:30]([NH:33][C:34]([C@H:36]1[CH2:41][CH2:40][C@@H:39]([NH:42][C:43]2[C:48]([N+:49]([O-])=O)=[CH:47][N:46]=[C:45]([O:52][CH2:53][CH2:54][O:55]C3CCCCO3)[CH:44]=2)[CH2:38][CH2:37]1)=[O:35])([CH3:32])[CH3:31]>>[NH2:49][C:48]1[C:43]([NH:42][C@@H:39]2[CH2:40][CH2:41][C@H:36]([C:34]([NH:33][CH:30]([CH3:32])[CH3:31])=[O:35])[CH2:37][CH2:38]2)=[CH:44][C:45]([O:52][CH2:53][CH2:54][OH:55])=[N:46][CH:47]=1

Participants

3

Reactant 2

HCID 178457857HCID 178457857, compoundHCID 178457864HCID 178457864, compound

Product 1

HCID 178457865HCID 178457865, compound

Procedure

The title compound was synthesized using a method analogous to the preparation of cis-4-(5-amino-2-(2-(piperidin-1-yl)ethoxy)pyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide starting from cis-N-isopropyl-4-(5-nitro-2-(2-(tetrahydro-2H-pyran-2-yloxy)ethoxy)pyridin-4-ylamino)cyclohexanecarboxamide, resulting in the deprotection of the -THP alcohol. MS m/z=337.2 [M+H], calc 336.43 for C17H28N4O3.

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-23cb4ec4bd834e42a87e69e39526b946
Source dataset
uspto-grants-2015_08
Patent number
US09115127B2

Reaction notes

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