Pyrrolidine → HCID 178457822, compound

Participants

Reaction Steps

The title compound was synthesized using a method analogous to the preparation of (E)-N-(1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-6-(2-(piperidin-1-yl)ethoxy)-1H-imidazo[4,5-c]pyridin-2(3H)-ylidene)morpholine-4-carboxamide, using pyrrolidine as the amine source (4.5% yield). MS m/z=526.5 [M+H], calc 525.69 for C28H43N7O3. 1H NMR (DMSO-d6) δ ppm: 11.77 (s., 1H), 7.98 (s, 1H), 7.62 (d, J=1.0 Hz, 1H), 6.79 (s, 1H), 4.45-4.58 (m, 1H), 4.30 (t, J=1.0 Hz, 2H), 3.85-4.00 (m, 1H), 3.43-3.53 (m, 2H), 3.30-3.36 (m, 2H), 2.61 (t, J=1.0 Hz, 2H), 2.52-2.59 (m, 2H), 2.36-2.47 (m, 5H), 2.01-2.10 (m, 2H), 1.75-1.86 (m, 4H), 1.53-1.65 (m, 2H), 1.43-1.53 (m, 6H), 1.32-1.42 (m, 2H), 1.08 (d, J=6.6 Hz, 6H).

Provenance & Evidence