HCID 178457848, compound → HCID 178457807, compound

HRID 518696Notes

Reaction equation

HRID 518696 reaction equation
[NH2:1][C:2]1[C:3]([NH:17][C@@H:18]2[CH2:23][CH2:22][C@H:21]([C:24]([NH:26][CH:27]([CH3:29])[CH3:28])=[O:25])[CH2:20][CH2:19]2)=[CH:4][C:5]([NH:8][CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[N:6][CH:7]=1.[F:30][C:31]1[CH:65]=[CH:64][C:34]([C:35](/[N:37]=[C:38]2/N([C@H]3CC[C@@H](C(=O)NC(C)C)CC3)C3C=C(OCCOC)N=CC=3N/2)=[O:36])=[CH:33][CH:32]=1>>[F:30][C:31]1[CH:32]=[CH:33][C:34]([C:35](/[N:37]=[C:38]2/[N:17]([C@H:18]3[CH2:23][CH2:22][C@@H:21]([C:24](=[O:25])[NH:26][CH:27]([CH3:29])[CH3:28])[CH2:20][CH2:19]3)[C:3]3[CH:4]=[C:5]([NH:8][CH2:9][CH2:10][N:11]4[CH2:16][CH2:15][O:14][CH2:13][CH2:12]4)[N:6]=[CH:7][C:2]=3[NH:1]/2)=[O:36])=[CH:64][CH:65]=1

Participants

3

Reactant 2

HCID 178457848HCID 178457848, compoundHCID 178496069HCID 178496069, compound

Product 1

HCID 178457807HCID 178457807, compound

Procedure

The title compound was prepared from cis-4-(5-amino-2-(2-morpholinoethylamino)pyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide using a procedure analogous to that used to prepare (E)-4-fluoro-N-(1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-6-(2-methoxyethoxy)-1H-imidazo[4,5-c]pyridin-2(3H)-ylidene)benzamide. Isolated as an off-white solid (23 mg, 23% yield). M/Z calc'd for C29H38FN7O3: 551.66. found 552 [M+H].

Sources & evidence

ORD record
ord-5f5061b9d913478990d57317f05ea98a
Source dataset
uspto-grants-2015_08
Patent number
US09115127B2

Reaction notes

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