4-(Piperidine-4-carbonyl)morpholine hydrochloride → HCID 178457794, 화합물

HRID 518712노트

반응식

HRID 518712 반응식
[F:1][C:2]1[CH:33]=[CH:32][C:5]([C:6](/[N:8]=[C:9]2\[NH:10][C:11]3[CH:29]=[CH:28][C:27]([CH2:30]O)=[CH:26][C:12]=3[N:13]\2[C@H:14]2[CH2:19][CH2:18][C@@H:17]([C:20](=[O:25])[NH:21][CH:22]([CH3:24])[CH3:23])[CH2:16][CH2:15]2)=[O:7])=[CH:4][CH:3]=1.Cl.[O:35]1[CH2:40][CH2:39][N:38]([C:41]([CH:43]2[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]2)=[O:42])[CH2:37][CH2:36]1.FC1C=CC(C(/N=C2\NC3C=CC(CN4CCN(S(C)(=O)=O)CC4)=CC=3N\2[C@H]2CC[C@@H](C(=O)NC(C)C)CC2)=O)=CC=1>>[F:1][C:2]1[CH:33]=[CH:32][C:5]([C:6](/[N:8]=[C:9]2\[NH:10][C:11]3[CH:29]=[CH:28][C:27]([CH2:30][N:46]4[CH2:47][CH2:48][CH:43]([C:41]([N:38]5[CH2:37][CH2:36][O:35][CH2:40][CH2:39]5)=[O:42])[CH2:44][CH2:45]4)=[CH:26][C:12]=3[N:13]\2[C@H:14]2[CH2:15][CH2:16][C@@H:17]([C:20](=[O:25])[NH:21][CH:22]([CH3:23])[CH3:24])[CH2:18][CH2:19]2)=[O:7])=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 27946894-(Piperidine-4-carbonyl)morpholine hydrochlorideHCID 178457797HCID 178457797, 화합물HCID 178457799HCID 178457799, 화합물

생성물 1

HCID 178457794HCID 178457794, 화합물

실험 절차

The title compound was prepared from (E)-4-fluoro-N-(6-(hydroxymethyl)-1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide and morpholino(piperidin-4-yl)methanone hydrochloride using a method analogous to that used in the preparation of (E)-4-fluoro-N-(1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide, with a reaction temperature of 50° C. for 4 hours. The title compound was isolated as a white powder (49 mg, 35.0% yield). MS, m/z (C35H45FN6O4): calcd, 632.4. found, 633.0 [M+H].

출처 및 근거

ORD 기록
ord-d3cc609d208a4454ad78da496a3049bb
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09115127B2

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