反应详情

The title compound was prepared from (E)-4-fluoro-N-(6-(hydroxymethyl)-1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide and morpholino(piperidin-4-yl)methanone hydrochloride using a method analogous to that used in the preparation of (E)-4-fluoro-N-(1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide, with a reaction temperature of 50° C. for 4 hours. The title compound was isolated as a white powder (49 mg, 35.0% yield). MS, m/z (C35H45FN6O4): calcd, 632.4. found, 633.0 [M+H].