Thionyl Chloride → HCID 178522615, compound

Participants

Reaction Conditions

Reaction Steps

To a 0° C. suspension of cis-4-((E)-2-(4-fluorobenzoylimino)-6-(morpholinomethyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexanecarboxylic acid (0.5 g, 1.041 mmol) in DCM (10.41 mL) was added thionyl chloride (0.380 mL, 5.20 mmol). The suspension was stirred for 30 minutes at 0° C. The reaction was concentrated, resuspended in ACN (5 mL), and reconcentrated to generate cis-4-((E)-2-(4-fluorobenzoylimino)-6-(morpholinomethyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexanecarbonyl chloride (0.50 g, 96% yield) as a white powder.

Provenance & Evidence