HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzoic Acid → N-[7-(dimethylcarbamoylmethyl-methyl-amino)-4-methoxy-benzothiazol-2-yl]-4-fluoro-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzoic Acid | HCID 9973 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Iodo-N,N-dimethylacetamide | HCID 52050 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 4-methoxy-N7-methyl-benzothiazole-2,7-diamine | HCID 22736978 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[7-(dimethylcarbamoylmethyl-methyl-amino)-4-methoxy-benzothiazol-2-yl]-4-fluoro-benzamide | HCID 10173236 | — |
Reaction Steps
From 4-methoxy-N7-methyl-benzothiazole-2,7-diamine with potassium carbonate and 2-iodo-N,N-dimethyl-acetamide in DMF, then treatment with 4-fluorobenzoic acid, HATU and N-ethyldiisopropylamine in THF. ES-MS m/e (%): 417 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713499B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-5f2c6b2f66ea485b89c80b899f9af508 |
| Source note | uspto-grants-2004_03 |