tert-Butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate → HCID 178458675, compound

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Reaction Steps

The title compound was prepared from cis-4-((E)-2-(4-fluorobenzoylimino)-6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexanecarboxylic acid and tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate using a method analogous to that used in the preparation of (E)-4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-(cis-4-(piperazine-1-carbonyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide (70 mg, 51% yield). MS, m/z (C41H55FN6O5): calcd, 730.4. found, 731.1 [M+H].

Provenance & Evidence