Hydrochloric Acid → HCID 178458674, compound

Participants

Reaction Steps

To a solution of tert-butyl 8-(cis-4-((E)-2-(4-fluorobenzoylimino)-6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexanecarbonyl)-3,8-diazabicyclo[3.2.1]octane-3-carboxylate (70 mg, 0.096 mmol) in DCM (2 mL) was added 4 M HCl in dioxane (0.120 mL, 0.479 mmol). The suspension was stirred overnight at RT. After 16 hours, the reaction was concentrated to provide (E)-N-(1-(cis-4-(3,8-diazabicyclo[3.2.1]octane-8-carbonyl)cyclohexyl)-6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1H-benzo[d]imidazol-2(3H)-ylidene)-4-fluorobenzamide dihydrochloride as a white powder (68 mg, 101% yield). MS, m/z (C36H47FN6O3.2HCl): calcd, 630.4. found, 631.2 [M+H].

Provenance & Evidence